Morpholine → 342412-40-2

HRID 730635Notes

Reaction equation

HRID 730635 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]#N)[CH2:10][CH2:9]1)C1C=CC=CC=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CO>[CH3:14][C:11]1([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 801891-Benzyl-4-hydroxypiperidine-4-carbonitrile

Product 1

HCID 12410239342412-40-2

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.25 g (23.8 mmol) 1-benzyl-4-hydroxy-piperidine-4-carbonitrile and 2.2 mL (25.2 mmol) morpholine in 30 mL MeOH was refluxed for 6 h. The mixture was evaporated to dryness i. vac., while the product was obtained in the form of crystals.

Workup

  1. customThe mixture was evaporated to dryness i
  2. custom, while the product was obtained in the form of crystals

Sources & evidence

ORD record
ord-901a78f16963470fb68bb834f2476408
Source dataset
uspto-grants-2009_09
Patent number
US07582625B2

Reaction notes

Loading…