HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-tert-butoxycarbonylmethoxy-[1,4']bipiperidinyl-1'-carboxylate → Tert-butyl([1,4']bipiperidinyl-4-yloxy)-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-tert-butoxycarbonylmethoxy-[1,4']bipiperidinyl-1'-carboxylate | HCID 66941898 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl([1,4']bipiperidinyl-4-yloxy)-acetate | HCID 86261192 | — |
Reaction Steps
A suspension of 3.08 g (7.12 mmol) of benzyl 4-tert-butoxycarbonylmethoxy-[1,4′]bipiperidinyl-1′-carboxylate and 300 mg of 10% Pd/C in 60 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 2 h. The catalyst was removed by suction filtering and the filtrate was evaporated to dryness. The oil remaining was reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582625B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f06395ffb5f348c78cc815568ae6f367 |
| Source note | uspto-grants-2009_09 |