HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-Benzyloxy-3,5-dimethyl-phenyl)-2-oxo-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Methyl 2-acetylamino-3-(4-benzyloxy-3,5-dimethyl-phenyl)-acrylate | HCID 67273532 | — |
| Product | 3-(4-Benzyloxy-3,5-dimethyl-phenyl)-2-oxo-propionic acid | HCID 67273873 | — |
Reaction Steps
31.1 g (88.1 mmol) methyl 2-acetylamino-3-(4-benzyloxy-3,5-dimethyl-phenyl)-acrylate in 150 mL 1,4-dioxane were combined with 125 mL 4 M HCl, refluxed for 7 h and stirred overnight at RT. The precipitate was suction filtered, washed with water and dried at 45° C. in the vacuum drying cupboard.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582625B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-982ab9af6a2a4d7f861910690aa3f1a7 |
| Source note | uspto-grants-2009_09 |