4-Morpholinopiperidine → Bi-44370

HRID 730653Notes

Reaction equation

HRID 730653 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:29](O)=[O:30])[CH2:19][C:20]3[CH:25]=[C:24]([CH3:26])[C:23]([OH:27])=[C:22]([CH3:28])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1.[NH:36]1[CH2:41][CH2:40][CH:39]([N:42]2[CH2:47][CH2:46][O:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:21]=[C:22]([CH3:28])[C:23]([OH:27])=[C:24]([CH3:26])[CH:25]=3)[C:29]([N:36]3[CH2:41][CH2:40][CH:39]([N:42]4[CH2:47][CH2:46][O:45][CH2:44][CH2:43]4)[CH2:38][CH2:37]3)=[O:30])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 7957244-MorpholinopiperidineHCID 67273812HCID 67273812, compound

Product 1

HCID 23654987Bi-44370

Procedure

Prepared analogously to Example 1i from 70 mg (0.15 mmol) (R)-2-(4-hydroxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 25 mg (0.15 mmol) 4-piperidin-4-yl-morpholine.

Sources & evidence

ORD record
ord-43937d57ccdc4f8b812efbad054d2939
Source dataset
uspto-grants-2009_09
Patent number
US07582625B2

Reaction notes

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