HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 4-Chloro-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| Reactant | 1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- | HCID 66937336 | — |
| Product | 4-Chloro-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 57835127 | — |
Reaction Steps
The benzoimidazole from step (b) above (69.3 mg, 0.3 mmol) reacted with 1-(3-trifluoromethylpyridin-2-yl)piperazine (128 mg, 0.5 mmol, Fluorochem) under the conditions of Example 1d to give the title compound as a white solid. M.p. 204° C. MS (ESI, pos. ion) m/z: 450 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f1db3f527ff8480e890acc6d8cace11a |
| Source note | uspto-grants-2009_09 |