Diisopropylethylamine → 4-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1-(3-Chloropyridin-2-yl)piperazine hydrochloride	HCID 20455074	—
Reactant	1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)-	HCID 66937336	—
Product	4-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole	HCID 57835192	—

Reaction Steps

The reaction of 1-(3-chloropyridin-2-yl)piperazine hydrochloride (99 mg, 0.5 mmol, Example 3b) and 2,4-dichloro-6-trifluoromethyl-1H-benzoimidazole (76 mg, 0.3 mmol, Example 5b) and N,N-diisopropylethylamine (0.17 mL, 1 mmol, Aldrich) under the conditions of Example 3c afforded the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 416 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07582761B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-251bf48d86f74d24bb1882a57b49aec7
Source note	uspto-grants-2009_09