HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dichloropyridin-2-yl)piperazine → 4-Bromo-2-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dichloropyridin-2-yl)piperazine | HCID 2771431 | — |
| Reactant | 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole | HCID 11594585 | — |
| Product | 4-Bromo-2-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 57835076 | — |
Reaction Steps
The piperazine from step (a) above (162 mg, 0.7 mmol) and 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (168 mg, 0.56 mmol, Example 6b) reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 176-179° C. MS (ESI, pos. ion) m/z: 495 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-9ca85a43e71d40f6afe9cf870ba4c1fd |
| Source note | uspto-grants-2009_09 |