2,3-Dichloropyridine → HCID 60701858, compound

HRID 730717Notes

Reaction equation

Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12]>>[CH3:9][O:10][C:11]([CH:13]1[CH2:18][CH2:17][N:16]([C:2]2[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:15][CH2:14]1)=[O:12]

Participants

Reactant 2

HCID 169882,3-Dichloropyridine

HCID 424914Methyl isonipecotate

Product 1

HCID 60701858HCID 60701858, compound

Procedure

2,3-Dichloropyridine (1.48 g, 10 mmol, Aldrich) and piperidine-4-carboxylic acid methyl ester (1.43 g, 10 mmol, Aldrich) were reacted under the conditions of Example 3a to give the title compound as a colorless viscous oil. MS (ESI, pos. ion) m/z: 256 (M+1).

Sources & evidence

ORD record: ord-2585a0863191410389eb2a1d0bbc2ff1
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582761B2

Reaction notes

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