Diisopropylethylamine → 6-tert-Butyl-2-[4-(3-chloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole

Participants

Reaction Steps

The benzoimidazole from step (b) above (0.209 g, 1 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.304 g, 1.3 mmol, Example 3b) and N,N-diisopropylethylamine (0.45 mL, 2.6 mmol, Aldrich) were reacted under the conditions of Example 1d to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 371 (M+1).

Provenance & Evidence