1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 6-tert-Butyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
Reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11](Cl)[NH:10][C:9]=2[CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]([F:30])([F:29])[C:17]1[C:18]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:19][CH:20]=[CH:21][CH:22]=1>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11]([N:26]3[CH2:27][CH2:28][N:23]([C:18]4[C:17]([C:16]([F:30])([F:15])[F:29])=[CH:22][CH:21]=[CH:20][N:19]=4)[CH2:24][CH2:25]3)[NH:10][C:9]=2[CH:14]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
The reaction of 6-tert-butyl-2-chloro-1H-benzoimidazole (0.209 g, 1 mmol, Example 17b) with 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.346 g, 1.65 mmol, Maybridge) under the conditions of Example 3c afforded the title compound as a white solid. M.P. 247-249° C. MS (ESI, pos. ion) m/z: 404 (M+1).
Sources & evidence
- ORD record
- ord-acf905db0e9f4dbf937487fb91de7f6b
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07582761B2
Reaction notes
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