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Diisopropylethylamine → 6-Bromo-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | — |
| 反応物 | HCID 178478307 | HCID 178478307 | — |
| 生成物 | 6-Bromo-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 57835018 | — |
反応手順
The 5-bromo-2-chloro-1H-benzoimidazole (0.115 g, 0.5 mmol, Example 23b), 1-(3-chloropyridin-2-yl)piperazine (0.198 g, 1 mmo, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 207-208° C. MS (ESI; pos.,ion) m/z: 394 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-ab3b91e3b62343a1ba301a51a729d74f |
| 出典メモ | uspto-grants-2009_09 |