2,5,6-Trichloro-1H-benzimidazole → HCID 57835131, compound

HRID 730730Notes

Reaction equation

HRID 730730 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([Cl:12])[C:9]([Cl:11])=[CH:10][C:4]=2[N:3]=1.[F:13][C:14]([F:28])([F:27])[C:15]1[C:16]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:17][CH:18]=[CH:19][CH:20]=1>>[Cl:12][C:8]1[C:9]([Cl:11])=[CH:10][C:4]2[NH:3][C:2]([N:24]3[CH2:25][CH2:26][N:21]([C:16]4[C:15]([C:14]([F:28])([F:13])[F:27])=[CH:20][CH:19]=[CH:18][N:17]=4)[CH2:22][CH2:23]3)=[N:6][C:5]=2[CH:7]=1

Participants

3

Reactant 2

HCID 2860092,5,6-Trichloro-1H-benzimidazoleHCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazine

Product 1

HCID 57835131HCID 57835131, compound

Procedure

The benzoimidazole from step (b) above (0.110 g, 0.5 mmol) and 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.231 g, 1 mmol, Maybridge) reacted under the conditions Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 416 (M+1).

Sources & evidence

ORD record
ord-0a4e9e0012b74b4cba024d5fd70fa22a
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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