tert-Butyl piperazine-1-carboxylate → HCID 11680966, compound

HRID 730742Notes

Reaction equation

HRID 730742 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][N:5]=[CH:4][N:3]=1.[N:9]1([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>>[C:18]([O:17][C:15]([N:9]1[CH2:14][CH2:13][N:12]([C:2]2[C:7]([Cl:8])=[CH:6][N:5]=[CH:4][N:3]=2)[CH2:11][CH2:10]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 115500374,5-dichloropyrimidine

Product 1

HCID 11680966HCID 11680966, compound

Procedure

The pyrimidine from step (b) above (1.75 g, 1.2 mmol) and tert-butyl 1-piperazinecarboxylate (2.235 g, 0.012 mol, Aldrich) reacted under the conditions of Example 3a to give the title compound as an orange oil. MS (ESI, pos. ion) m/z: 299 (M+1).

Sources & evidence

ORD record
ord-71700e6fa7d34331b51d4353e0566bcf
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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