3,5-Dichloro-2-fluoropyridine → Methyl 4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)-3-methylbenzoate

HRID 73075Notes

Reaction equation

HRID 73075 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:10][C:11]1[CH:12]=[C:13]([CH:18]=[CH:19][C:20]=1[S:21](=[O:35])(=[O:34])[NH:22][CH2:23][C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[N:29]([CH3:33])[CH:28]=[CH:27]2)[C:14]([O:16][CH3:17])=[O:15]>>[Cl:1][C:2]1[C:3]([N:22]([CH2:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[N:29]([CH3:33])[CH:28]=[CH:27]3)[S:21]([C:20]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][C:11]=2[CH3:10])(=[O:34])=[O:35])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837917HCID 66837917, compound

Product 1

HCID 66837825Methyl 4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)-3-methylbenzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and methyl 3-methyl-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 11).

Sources & evidence

ORD record
ord-205196201fb042cb98ce0cd0b4c61632
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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