Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- → (2-{4-[7-Chloro-5-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl}pyridin-3-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- | HCID 66937336 | — |
| 반응물 | 2-(1-piperazinyl)-3-Pyridinemethanol | HCID 67400406 | — |
| 생성물 | (2-{4-[7-Chloro-5-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl}pyridin-3-yl)methanol | HCID 178519687 | — |
반응 단계
The piperazine from step (a) above (97 mg, 0.5 mmol) reacted with 2,4-dichloro-6-trifluoromethyl-1H-benzoimidazole (85 mg, 0.33 mmol, Example 5b) under the conditions of Example 3c to give the title compound as a white solid. M.p. 252° C. MS (ESI, pos. ion) m/z: 412 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582761B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-e55546e3e8bb4bc496b4f6889bddc0df |
| 출처 메모 | uspto-grants-2009_09 |