2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 11647318, compound

HRID 730762Notes

Reaction equation

HRID 730762 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[C:4]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.Cl[C:18]1[NH:22][C:21]2[CH:23]=[C:24]([C:27]([F:30])([F:29])[F:28])[CH:25]=[CH:26][C:20]=2[N:19]=1>>[F:30][C:27]([F:28])([F:29])[C:24]1[CH:25]=[CH:26][C:20]2[N:19]=[C:18]([N:12]3[CH2:11][CH2:10][N:9]([C:4]4[C:3]([C:2]([F:1])([F:15])[F:16])=[CH:8][CH:7]=[CH:6][N:5]=4)[CH2:14][CH2:13]3)[NH:22][C:21]=2[CH:23]=1

Participants

3

Reactant 2

HCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazine

Product 1

HCID 11647318HCID 11647318, compound

Procedure

The title compound was prepared from 1-(3-trifluoromethylpyridin-2-yl)piperazine (Maybridge) and 2-chloro-6-trifluoromethyl-1H-benzoimidazole (Example 1c) under the conditions of Example 3c. MS (ESI, pos. ion) m/z: 416 (M+1). M.p. 221-224° C.

Sources & evidence

ORD record
ord-177a8df8d4aa40e98d09788cf9ff218b
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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