2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178486270, compound

HRID 730765Notes

Reaction equation

HRID 730765 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)(=[O:5])=[O:4].Cl[C:19]1[NH:23][C:22]2[CH:24]=[C:25]([C:37]([F:40])([F:39])[F:38])[CH:26]=[C:27]([C:28]3[CH:33]=[C:32]([F:34])[C:31]([F:35])=[C:30]([F:36])[CH:29]=3)[C:21]=2[N:20]=1>>[CH3:1][NH:2][S:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][N:15]([C:19]3[NH:20][C:21]4[C:27]([C:28]5[CH:29]=[C:30]([F:36])[C:31]([F:35])=[C:32]([F:34])[CH:33]=5)=[CH:26][C:25]([C:37]([F:40])([F:38])[F:39])=[CH:24][C:22]=4[N:23]=3)[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazoleHCID 674013562-Piperazin-1-yl-pyridine-3-sulfonic acid methylamide

Product 1

HCID 178486270HCID 178486270, compound

Procedure

The piperazine from step (a) above (128 mg, 0.5 mmol) reacted with 2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole (140 mg, 0.4 mmol, Example 51b) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 571 (M+1).

Sources & evidence

ORD record
ord-1d516d134b984aad914a27abe80bd7a3
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

Loading…