1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → HCID 178526651, compound

HRID 730768Notes

Reaction equation

HRID 730768 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[F:18][C:19]([F:33])([F:32])[C:20]1[C:21]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:22][CH:23]=[CH:24][CH:25]=1>>[N+:11]([C:10]1[C:4]2[NH:3][C:2]([N:29]3[CH2:30][CH2:31][N:26]([C:21]4[C:20]([C:19]([F:33])([F:18])[F:32])=[CH:25][CH:24]=[CH:23][N:22]=4)[CH2:27][CH2:28]3)=[N:6][C:5]=2[CH:7]=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:9]=1)([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazineHCID 116375342-chloro-4-nitro-6-(trifluoromethyl)-1H-benzoimidazole

Product 1

HCID 178526651HCID 178526651, compound

Procedure

The benzoimidazole from step (c) above (1.5 g, 5.7 mmol) and 1-(3-trifluoromethylpyridin-2-yl)piperazine (1.8 g, 7.8 mmol, Matrix) reacted under the conditions of Example 3c to give the title compound as a orange solid. M.p. 192° C. MS (ESI, pos. ion) m/z: 461 (M+1).

Sources & evidence

ORD record
ord-7ccf024788af45b89f6b451919d088c3
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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