HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1H-Benzimidazole, 2-chloro-7-iodo-5-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Iodo-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 67401177 | — |
| Product | 1H-Benzimidazole, 2-chloro-7-iodo-5-(trifluoromethyl)- | HCID 67401406 | — |
Reaction Steps
4-Iodo-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one (328 mg, 1 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a off-white solid. MS (ESI, pos. ion) m/z: 347(M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c592857dda02446fa798c02e9d3a851a |
| Source note | uspto-grants-2009_09 |