(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol → HCID 178519829, compound

HRID 730774Notes

Reaction equation

HRID 730774 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:10]([I:11])[C:4]=2[N:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH2:29][OH:30])[CH:20]=[N:21][C:22]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Cl:16][C:17]1[CH:18]=[C:19]([CH2:29][OH:30])[CH:20]=[N:21][C:22]=1[N:23]1[CH2:28][CH2:27][N:26]([C:2]2[NH:3][C:4]3[C:10]([I:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][C:5]=3[N:6]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 11514124(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanolHCID 674014061H-Benzimidazole, 2-chloro-7-iodo-5-(trifluoromethyl)-

Product 1

HCID 178519829HCID 178519829, compound

Procedure

The benzoimidazole from step (c) above (69 mg, 0.2 mmol) reacted with (5-chloro-6-piperazin-1-yl-pyridin-3-yl)methanol (68 mg, 0.3 mmol, Example 60c) under the conditions of Example 3c to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 538 (M+1).

Sources & evidence

ORD record
ord-9838199bfd6a4e28905982d802926244
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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