HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine, (R)- → {5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Reactant | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| Product | {5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol | HCID 11550484 | — |
Reaction Steps
A mixture of 5,6-dichloro-3-pyridinemethanol (0.35 g, 2 mmol, TCI-US) and (R)-(−)-2-methylpiperazine (0.3 g. 3 mmol, Aldrich) reacted under the conditions of Example 43a to give the title compound as a light-brown solid. MS (ESI, pos. ion) m/z: 242 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-240327d833cb45a6b644347a35b29d43 |
| Source note | uspto-grants-2009_09 |