2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178461516, compound

HRID 730780Notes

Reaction equation

HRID 730780 reaction equation
[Br:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][NH:11][C@@H:10]([CH3:14])[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl[C:16]1[NH:20][C:19]2[CH:21]=[C:22]([C:34]([F:37])([F:36])[F:35])[CH:23]=[C:24]([C:25]3[CH:30]=[C:29]([F:31])[C:28]([F:32])=[C:27]([F:33])[CH:26]=3)[C:18]=2[N:17]=1>>[Br:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11]([C:16]3[NH:17][C:18]4[C:24]([C:25]5[CH:26]=[C:27]([F:33])[C:28]([F:32])=[C:29]([F:31])[CH:30]=5)=[CH:23][C:22]([C:34]([F:37])([F:35])[F:36])=[CH:21][C:19]=4[N:20]=3)[C@@H:10]([CH3:14])[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazoleHCID 11658915HCID 11658915, compound

Product 1

HCID 178461516HCID 178461516, compound

Procedure

The piperazine from step (a) above (51 mg, 0.2 mmol) reacted with 2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole (53 mg, 0.15 mmol, Example 51b) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 570 (M+1).

Sources & evidence

ORD record
ord-a77c4965963b4fa9851ef9e40e016dc6
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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