3-Fluoro-4-methoxyphenylboronic acid → HCID 178488593, compound

HRID 730784Notes

Reaction equation

HRID 730784 reaction equation
Br[C:2]1[C:7]2[NH:8][C:9]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[N:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][C:18]=4[Cl:25])[CH2:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[F:30][C:31]1[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][C:36]=1[O:37][CH3:38]>>[Cl:25][C:18]1[CH:19]=[C:20]([CH2:23][OH:24])[CH:21]=[N:22][C:17]=1[N:14]1[CH2:13][CH2:12][N:11]([C:9]2[NH:8][C:7]3[C:2]([C:33]4[CH:34]=[CH:35][C:36]([O:37][CH3:38])=[C:31]([F:30])[CH:32]=4)=[CH:3][C:4]([C:26]([F:29])([F:27])[F:28])=[CH:5][C:6]=3[N:10]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 27821943-Fluoro-4-methoxyphenylboronic acidHCID 178519826HCID 178519826, compound

Product 1

HCID 178488593HCID 178488593, compound

Procedure

(6-{4-[7-Bromo-5-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl}-5-chloropyridin-3-yl)methanol from step (a) above (98 mg, 0.2 mmol) and 3-fluoro-4-methoxyphenylboronic acid (43 mg, 0.25 mmol, Aldrich) reacted under the conditions of Example 51 to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 536 (M+1).

Sources & evidence

ORD record
ord-1bea61ecd3bc47cfa58630a8f856d859
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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