2,3-Dichloropyridine → (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine

HRID 730787Notes

Reaction equation

HRID 730787 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:9][C@@H:10]1[CH2:15][NH:14][CH2:13][CH2:12][NH:11]1>>[Cl:8][C:7]1[C:2]([N:14]2[CH2:13][CH2:12][NH:11][C@H:10]([CH3:9])[CH2:15]2)=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 169882,3-DichloropyridineHCID 73304342-Methylpiperazine, (R)-

Product 1

HCID 11658551(3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine

Procedure

A mixture of 2,3-dichloropyridine (0.74 g, 5 mmol, Aldrich) and (R)-(−)-2-methylpiperazine (0.6 g. 6 mmol, Aldrich) reacted under the conditions of Example 43a to give the title compound as a off-white solid. MS (ESI, pos. ion) m/z: 212 (M+1).

Workup

  1. customreacted under the conditions of Example 43a

Sources & evidence

ORD record
ord-54b4e251f7614495af9b4601941f9aca
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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