2-Chloro-3-(trifluoromethyl)pyridine → (R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine

HRID 730792Notes

Reaction equation

HRID 730792 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][C@@H:13]1[CH2:18][NH:17][CH2:16][CH2:15][NH:14]1>>[CH3:12][C@H:13]1[NH:14][CH2:15][CH2:16][N:17]([C:2]2[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:18]1

Participants

3

Reactant 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 73304342-Methylpiperazine, (R)-

Product 1

HCID 11528875(R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine

Procedure

A mixture of 2-chloro-3-trifluoromethylpyridine (1.45 g, 8 mmol, Aldrich) and (R)-(−)-2-methylpiperazine (1.0 g. 10 mmol, Aldrich) was reacted under the conditions of Example 43a to give the title compound as a off-white solid. MS (ESI, pos. ion) m/z: 246 (M+1).

Workup

  1. customwas reacted under the conditions of Example 43a

Sources & evidence

ORD record
ord-0ac8dd6963a745c5b465b796ed0c09ca
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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