HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 5-Chloro-6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| Reactant | 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)- | HCID 178506058 | — |
| Product | 5-Chloro-6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole | HCID 57835141 | — |
Reaction Steps
The benzoimidazole from step (c) above (255 mg, 1.0 mmol) reacted with 1-(3-trifluoromethylpyridin-2-yl)piperazine (231 mg, 1.0 mmol, Oakwood) under the conditions of Example 3c to give the title compound as a white solid. M.p. 206.4-208.1° C. MS (ESI, pos. ion) m/z: 450.4 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3cf1189119334fe38f3098802bfd4b6d |
| Source note | uspto-grants-2009_09 |