HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloropyridin-2-yl)piperazine hydrochloride → 5-Chloro-2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| Reactant | 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)- | HCID 178506058 | — |
| Product | 5-Chloro-2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 10341827 | — |
Reaction Steps
2,5-Dichloro-6-(trifluoromethyl)benzoimidazole (255 mg, 1.0 mmol, Example 84c) reacted with 1-(3-chloropyridin-2-yl)piperazine hydrochloride (233 mg, 1.0 mmol, Example 3b) under the conditions of Example 3c to give the title compound as a white solid. M.p. 208.9-211.0° C. MS (ESI, pos. ion) m/z: 416.3, 420.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e719cac210d04ca1bbb444cd413788af |
| Source note | uspto-grants-2009_09 |