N,N-Dimethylethylenediamine → HCID 67401327, compound

Participants

Reaction Steps

A mixture of 4-(5-bromo-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (b) above (174 mg, 0.42 mmol), N-(2-aminoethyl)-N,N-dimethylamine (56 μL, 0.51 mmol, Aldrich), tris (dibenzylideneacetone) dipalladium (0) chloroform adduct (22 mg, 0.021 mmol, Strem Chemicals), biphenyl-2-yl-di-tert-butyl-phosphane (13 mg, 0.042 mmol, Strem Chemicals), sodium t-butoxide (65 mg, 0.63 mmol, Aldrich) in toluene (2 mL) was subjected to microwave irradiation at 150° C. for 0.5 h. The mixture was cooled to room temperature and was filtered. The filtrate was purified by silica gel column chromatography, eluting with 5%-100% (2M NH3 in MeOH) in dichloromethane, to give the title product as a brown solid. MS (ESI, positive ion) m/z: 418 (M+1).

Provenance & Evidence