tert-Butyl piperazine-1-carboxylate → 4-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester

HRID 730847Notes

Reaction equation

HRID 730847 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[CH:4]=[CH:3][N:2]=1.[C:19]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[C:22]([O:21][C:19]([N:26]1[CH2:31][CH2:30][N:29]([C:8]2[CH:9]=[C:10]3[C:5]([CH:4]=[CH:3][N:2]=[CH:1]3)=[CH:6][CH:7]=2)[CH2:28][CH2:27]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 15171928Isoquinolin-7-yl trifluoromethanesulfonate

Product 1

HCID 674009894-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The product from step (a) above (300 mg, 1.1 mmol) and 1-BOC-piperazine (307 mg, 1.6 mmol, Aldrich) was reacted under the conditions of Example 132b to give the title compound as yellow amorphous solid, which was used for the next step. MS (ESI, pos. ion) m/z: 314 (M+1).

Sources & evidence

ORD record
ord-13b1dcd770fc47239e3916d00f7ab20c
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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