HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine → 4-bromo-2-[(2R)-4-(3,5-dichloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine | HCID 67402021 | — |
| Reactant | HCID 178506061 | HCID 178506061 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-bromo-2-[(2R)-4-(3,5-dichloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 57835191 | — |
Reaction Steps
A mixture of the piperazine from step (a) above (148 mg, 0.6 mmol) and 7-bromo-2-chloro-5-trifluoromethyl-1H-benzoimidazole (150 mg, 0.5 mmmol, Example 6b) in dioxane (2 mL) reacted under the conditions of Example 3c to give the title compound. Mp: 135-137° C. MS (ESI, pos. ion) m/z: 510 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d3c7bd3b48eb4d12a162d14c62bd2f87 |
| Source note | uspto-grants-2009_09 |