2-Methylpiperazine, (R)- → HCID 67400341, compound

HRID 730863Notes

Reaction equation

HRID 730863 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([CH2:9][O:10][CH3:11])=[CH:4][N:3]=1.[CH3:12][C@@H:13]1[CH2:18][NH:17][CH2:16][CH2:15][NH:14]1>>[Cl:8][C:7]1[C:2]([N:17]2[CH2:16][CH2:15][NH:14][C@H:13]([CH3:12])[CH2:18]2)=[N:3][CH:4]=[C:5]([CH2:9][O:10][CH3:11])[CH:6]=1

Participants

3

Reactant 2

HCID 73304342-Methylpiperazine, (R)-HCID 111379602,3-Dichloro-5-(methoxymethyl)pyridine

Product 1

HCID 67400341HCID 67400341, compound

Procedure

A mixture of 2,3-dichloro-5-methoxymethyl-pyridine from step (a) above (370 mg, 1.93 mmol) and (R)-(−)-2-methyl-piperazine (231 mg, 2.3 mmol, Aldrich) reacted under the condition of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 256 (M+1).

Workup

  1. customreacted under the condition of Example 3a

Sources & evidence

ORD record
ord-b131a34efd4d4f7aa3d57fddf0ec8a18
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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