1-(5,6-Dichloropyridin-3-yl)ethan-1-one → 2-(5,6-Dichloropyridin-3-yl)propan-2-ol

HRID 730875Notes

Reaction equation

HRID 730875 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[N:6][C:7]=1[Cl:8].[CH3:12][Mg+].[Br-]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:11])([CH3:12])[CH3:10])[CH:5]=[N:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 101980061-(5,6-Dichloropyridin-3-yl)ethan-1-oneHCID 178418689HCID 178418689, compound

Product 1

HCID 772303002-(5,6-Dichloropyridin-3-yl)propan-2-ol

Procedure

1-(5,6-Dichloro-pyridin-3-yl)-ethanone from step (a) above (300 mg, 1.58 mmol) reacted with MeMgBr (0.79 mL, 2.4 mmol, 3.0 M in ether, Aldrich) under the conditions of Example 154b to give the title compound. MS (ESI, pos. ion) m/z: 206 (M+1).

Sources & evidence

ORD record
ord-ec2d5ce644c04150bb7e944be1b4e840
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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