3,4,5-Trifluorobenzoic acid → 3,4,5-Trifluoro-N-(2-oxo-6-trifluoromethyl-2,3-dihydro-1H-benzoimidazol-4-yl)-benzamide

Participants

Reaction Steps

4-Amino-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one (2.17 g, 10 mmol, Example 61a) and 3,4,5-trifluoro-benzoic acid (1.94 g, 11 mmol, Aldrich) reacted under the conditions of Example 65 to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 376 (M+1), (ESI, neg. ion) m/z: 374 (M−1)

Provenance & Evidence