{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461548, compound

HRID 730887Notes

Reaction equation

HRID 730887 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.Cl[C:18]1[NH:19][C:20]2[C:26]([NH:27][C:28](=[O:38])[C:29]3[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=3)=[CH:25][C:24]([C:39]([F:42])([F:41])[F:40])=[CH:23][C:21]=2[N:22]=1>CCO>[Cl:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][N:11]([C:18]3[NH:19][C:20]4[C:26]([NH:27][C:28](=[O:38])[C:29]5[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=5)=[CH:25][C:24]([C:39]([F:42])([F:40])[F:41])=[CH:23][C:21]=4[N:22]=3)[C@H:10]([CH3:14])[CH2:9]2)=[N:6][CH:5]=[C:4]([CH2:15][OH:16])[CH:3]=1

Participants

4

Reactant 2

HCID 11550484{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanolHCID 178522153HCID 178522153, compound

Product 1

HCID 178461548HCID 178461548, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of {5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl}-methanol (530 mg, 2.2 mmol, Example 150a) and N-(2-chloro-6-trifluoromethyl-3H-benzoimidazol-4-yl)-3,4,5-trifluoro-benzamide from step (d) above (787 mg, 2.0 mmol) in EtOH (2 mL, Aldrich) reacted under the conditions of Example 3c to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 599 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-ea3f5c9c7d8b4e948350b209778f464e
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

Loading…