HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpiperazine-2-carboxamide → 4(3-Chloro-5-hydroxymethyl-pyridin-2-yl)-piperazine-2-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpiperazine-2-carboxamide | HCID 14722545 | — |
| Reactant | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| Product | 4(3-Chloro-5-hydroxymethyl-pyridin-2-yl)-piperazine-2-carboxylic acid methylamide | HCID 67400479 | — |
Reaction Steps
Piperazine-2-carboxylic acid methylamide from step (c) above (570 mg, 4.0 mmol) and (5,6-dichloro-pyridin-3-yl)-methanol (710 mg, 4.0 mmol, TCI-US) reacted under the conditions of Example 3a to give the title compound as a light-yellow gum. MS ESI, pos. ion) m/e: 285 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-1a708a14f60a4bdd988004b2dde96257 |
| Source note | uspto-grants-2009_09 |