{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461534, compound

HRID 730908Notes

Reaction equation

HRID 730908 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.Cl[C:18]1[NH:22][C:21]2[CH:23]=[C:24]([C:36]([F:39])([F:38])[F:37])[CH:25]=[C:26]([C:27]3[CH:32]=[C:31]([F:33])[C:30]([F:34])=[C:29]([F:35])[CH:28]=3)[C:20]=2[N:19]=1>CCO>[CH3:14][C@H:10]1[N:11]([C:18]2[NH:19][C:20]3[C:26]([C:27]4[CH:32]=[C:31]([F:33])[C:30]([F:34])=[C:29]([F:35])[CH:28]=4)=[CH:25][C:24]([C:36]([F:39])([F:38])[F:37])=[CH:23][C:21]=3[N:22]=2)[CH2:12][CH2:13][N:8]([C:7]2[N:6]=[CH:5][C:4]([CH2:15][OH:16])=[CH:3][C:2]=2[C:36]([F:39])([F:38])[F:37])[CH2:9]1

Participants

4

Reactant 2

HCID 11550484{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanolHCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole

Product 1

HCID 178461534HCID 178461534, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of {5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl}-methanol from step (g) above (825 mg, 3.0 mmol) and 2-chloro-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (1.05 g, 3.0 mmol, Example 51b) in EtOH (5 mL) reacted under the conditions of Example 3c to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 590 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-139bca9fe0b5425490fdc29d332eb368
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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