2,3-Dichloro-5-(trifluoromethyl)pyridine → Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-(2-methoxyethyl)-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

HRID 73094Notes

Reaction equation

HRID 73094 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[CH3:13][O:14][CH2:15][CH2:16][N:17]1[C:25]2[C:20](=[CH:21][C:22]([CH2:26][NH:27][S:28]([C:31]3[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=3)(=[O:30])=[O:29])=[CH:23][CH:24]=2)[CH:19]=[N:18]1>>[Cl:8][C:7]1[C:2]([N:27]([CH2:26][C:22]2[CH:21]=[C:20]3[C:25](=[CH:24][CH:23]=2)[N:17]([CH2:16][CH2:15][O:14][CH3:13])[N:18]=[CH:19]3)[S:28]([C:31]2[CH:32]=[CH:33][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:39][CH:40]=2)(=[O:30])=[O:29])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

Participants

3

Reactant 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 66837866HCID 66837866, compound

Product 1

HCID 66837903Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-(2-methoxyethyl)-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 4-(N-((1-(2-methoxyethyl)-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-3 of Example 20).

Sources & evidence

ORD record
ord-9fd722d0a0a5474980d833d466e5d065
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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