Triethylamine → HCID 57835390, compound

Participants

Reaction Steps

A solution of 1-{4-[1-ethyl-1-(5-hydroxy-benzo[b]thiophen-2-yl)-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (260 mg, 0.612 mmol) in CH2Cl2 (20 mL) at RT is treated with Et3N (0.40 mL) and methanesulfonyl chloride (140 mg, 1.22 mmol). The mixture is stirred for 30 min and quenched with water (1.0 mL). The organic layer is concentrated and purified using silica gel column chromatography (25% EtOAc/Hex) to afford the title compound (190 mg, 62%). NMR (ppm, CDCl3), δ: 7.67 (1 H, d, J=8.8 Hz), 7.59 (1 H, d, J=2.2 Hz), 7.13 (1 H, dd, J=2.2, 8.8 Hz), 7.11 (1 H, s), 7.01-7.04 (2 H, m), 6.51 (1 H, d, J=8.4 Hz), 4.84 (2 H, s), 3.16 (3 H, s), 2.26 (3 H, s), 2.15 (4 H, q, J=7.5 Hz), 1.26 (9 H, s), 0.74 (6H, t, J=7.5 Hz).

Provenance & Evidence