Water → HCID 10899632, compound

Participants

Reaction Steps

A solution of 0.12 g (0.45 mmol) of (2R,3S)-1-chloro-2-(2,4-difluorophenyl)butane-2,3-diol in methanol 3 mL was cooled in ice, and 0.12 g (0.6 mmol) of a 28% solution of NaOMe in methanol was added. Reaction was performed for 2 hours. Then, 10 mL of water was added to stop the reaction, and extraction was performed with ethyl acetate (10 mL). After drying over anhydrous sodium sulfate, concentration was performed under reduced pressure to obtain a crude product. The resulting crude product was purified by column on silica gel to obtain 0.086 g of the title compound (yield: 96%).

Provenance & Evidence