p-Toluenesulfonic acid monohydrate → (2R,3R)-1-Chloro-2-(2,4-difluorophenyl)butane-2,3-diol

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Reaction Steps

A mixed solution of 0.15 g (0.47 mmol) of (2R,3R)-1-chloro-2-(2,4-difluorophenyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)butan-2-ol, 5 mL of methanol, and 0.02 g of p-toluenesulfonic acid monohydrate was stirred at room temperature for 30 minutes. Concentration was performed under reduced pressure to obtain a crude product. The resulting product was purified by column on silica gel to obtain 0.12 g of the title compound (yield: 97%).

Provenance & Evidence