Water → HCID 14706434, compound

Participants

Reaction Steps

To a solution of 0.10 g of (2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol in 1 mL of THF was added 0.3 mL of TBAF (1 M) at room temperature. Stirring was performed at room temperature for 3.5 hours, and 5 mL of water was added thereto. Then, extraction was performed with ethyl acetate (30 mL). After drying over anhydrous sodium sulfate, concentration was performed under reduced pressure to obtain a crude product. The resulting product was purified by column on silica gel to obtain 0.61 g of the title compound (yield: 87%). 1H-NMR (400 MHz, CDCl3) δ: 0.97 (d, 3H, J=6.3 Hz), 4.31 (q, 1H, J=6.3 Hz), 4.79-4.82 (m, 2H), 6.67-6.81 (m, 2H), 7.32-7.38 (m, 1H), 7.72 (s, 1H), 7.93 (s, 1H).

Provenance & Evidence