Potassium Carbonate → HCID 68815118, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1,3-dimethyl-2-phenyl-1H-indol-5-yl)-phenol (0.353 g, 1.126 mmol) was reacted with K2CO3 (0.189 g, 1.352 mmol) and bromoacetonitrile (0.162 g, 1.352 mmol) in acetone (15 ml) to give the desired product (0.362 g, 1.027 mmol, 91%) as a white solid, mp 177-179° C. 1H NMR (DMSO-d6) δ 2.25 (s, 3H), 3.61 (s, 3H), 5.21 (s, 2H), 7.15 (d, J=8.7 Hz, 2H), 7.45-7.52 (m, 5H), 7.55 (t, J=7.5 Hz, 2H), 7.72 (d, J=8.9 Hz, 2H), 7.78 (s, 1H); [EI], m/z 352 (M)+.

Provenance & Evidence