Potassium Carbonate → HCID 68814203, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1-benzyl-2,3-dimethyl-1H-indol-5-yl)-phenol (0.300 g, 0.916 mmol) was reacted with K2CO3 (0.152 g, 1.099 mmol) and bromoacetonitrile (0.132 g, 1.099 mmol) in acetone (10 ml) to give the product (0.207 g, 0.565 mmol, 62%) as a pale-blue solid, mp 167-169° C. 1H NMR (DMSO-d6) δ 2.25 (s, 3H), 2.28 (s, 3H), 5.19 (s, 2H), 5.39 (s, 2H), 6.98 (d, J=7.5 Hz, 2H), 7.12 (d, J=8.6 Hz, 2H), 7.21 (t, J=7.2 Hz, 1H), 7.26-7.30 (m, 3H), 7.39 (d, J=8.4 Hz, 1H), 7.65-7.67 (m, 3H); [ESI(+)], m/z 367 (M+H)+.

Provenance & Evidence