Potassium Carbonate → HCID 68814430, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(9-methyl-6,7,8,9-tetrahydro-5H-carbazol-3-yl)-phenol (0.194 g, 0.699 mmol) was reacted with K2CO3 (0.116 g, 0.839 mmol) and bromoacetonitrile (0.101 g, 0.839 mmol) in acetone (8 ml) to give the product (0.153 g, 0.484 mmol, 69%) as a white solid, mp 204-206° C. 1H NMR (DMSO-d6) δ 1.77-1.82 (m, 2H), 1.84-1.90 (m, 2H), 2.67 (t, J=5.8 Hz, 2H), 2.72 (t, J=5.8 Hz, 2H), 3.61 (s, 3H), 5.19 (s, 2H), 7.12 (d, J=8.7 Hz, 2H), 7.33 (dd, J=1.4, 8.4 Hz, 1H), 7.40 (d, J=8.6 Hz, 1H), 7.59 (s, 1H), 7.65 (d, J=8.6 Hz, 2H); [ESI(+)], m/z 317 (M+H)+.

Provenance & Evidence