Potassium Carbonate → HCID 68814337, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(3-benzyl-1,2-dimethyl-1H-indol-5-yl)-phenol (0.159 g, 0.486 mmol) was reacted with K2CO3 (0.087 g, 0.631 mmol) and bromoacetonitrile (0.076 g, 0.631 mmol) in acetone (5 ml) to give the product (0.161 g, 0.439 mmol, 90%) as a white solid, mp 135-138° C. 1H NMR (DMSO-d6) δ 2.40 (s, 3H), 3.68 (s, 3H), 4.07 (s, 2H), 5.18 (s, 2H), 7.08-7.12 (m, 3H), 7.20-7.25 (m, 4H), 7.32 (dd, J=1.8, 8.6 Hz, 1H), 7.41 (d, J=8.4 Hz, 1H), 7.57-7.60 (m, 3H); [ESI(+)], m/z 367 (M+H)+.

Provenance & Evidence