Benzyl Bromide → HCID 68816825, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 2 of example 3. Thus, 6-bromo-3-methyl-2-phenyl-1H-indole (1.284 g, 4.489 mmol) was reacted with k-t-butoxide (0.529 g, 4.711 mmol) and benzyl bromide (0.809 g, 4.711 mmol) in DMF (10 ml) to give the product (1.440 g, 3.827 mmol, 85%) as a white solid, mp 97-101° C. 1H NMR (DMSO-d6)δ 2.20 (s, 3H), 5.32 (s, 2H), 6.79-6.80 (m, 2H), 7.14-7.21 (m, 4H), 7.36-7.39 (m, 2H), 7.43 (t, J=7.2 Hz, 1H), 7.48 (t, J=6.9 Hz, 2H), 7.53 (d, J=8.4 Hz, 1H), 7.60 (d, J=1.7 Hz, 1H); [ESI(+)], m/z 376/378 (M+H)+.

Provenance & Evidence