Potassium Carbonate → HCID 68813999, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1-benzyl-3-methyl-2-phenyl-1H-indol-6-yl)-phenol (0.291 g, 0.747 mmol) was reacted with K2CO3 (0.124 g, 0.896 mmol) and bromoacetonitrile (0.107 g, 0.896 mmol) in acetone (5 ml) to give the product (0.284 g, 0.663 mmol, 89%) as a white solid, mp 146-150° C. 1H NMR (DMSO-d6) δ 2.20 (s, 3H), 5.15 (s, 2H), 5.36 (s, 2H), 6.82 (d, J=7.0 Hz, 2H), 7.08-7.17 (m, 5H), 7.32-7.47 (m, 4H), 7.45 (t, J=6.7 Hz, 2H), 7.57-7.63 (m, 4H); [ESI(+)], m/z 429 (M+H)+.

Provenance & Evidence