Potassium Carbonate → HCID 68814951, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(1-benzyl-3-methyl-2-phenyl-1H-indol-6-yl)-phenol (0.291 g, 0.747 mmol) was reacted with K2CO3 (0.134 g, 0.971 mmol) and methyl bromoacetate (0.149 g, 0.971 mmol) in acetone (5 ml) to give the product (0.305 g, 0.661 mmol, 88%) as a white solid, mp 145-148° C. 1H NMR (DMSO-d6) δ 2.24 (s, 3H), 3.70 (s, 3H), 4.81 (s, 2H), 5.39 (s, 2H), 6.86 (d, J=7.2 Hz, 2H), 6.98 (d, J=8.9 Hz, 2H), 7.13 (t, J=7.2 Hz, 1H), 7.18 (t, J=7.0 Hz, 2H), 7.34 (dd, J=1.4, 8.1 Hz, 1H), 7.39-7.44 (m, 3H), 7.49 (t, J=7.0 Hz, 2H,) 7.56-7.62 (m, 4H); [ESI(+)], m/z 462 (M+H)+.

Provenance & Evidence