Potassium Carbonate → HCID 68814808, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1-benzyl-3-methyl-2-phenyl-1H-indol-4-yl)-phenol (0.260 g, 0.668 mmol) was reacted with K2CO3 (0.111 g, 0.802 mmol) and bromoacetonitrile (0.096 g, 0.802 mmol) in acetone (5 ml) to give the product (0.271 g, 0.633 mmol, 95%) as a viscous oil. 1H NMR (DMSO-d6) δ 1.72 (s, 3H), 5.22 (s, 2H), 5.33 (s, 2H), 6.85-6.89 (m, 3H), 7.11-7.14 (m, 3H), 7.17 (t, J=7.2 Hz, 1H), 7.22 (t, J=7.0 Hz, 2H), 7.33-7.35 (m, 3H), 7.39-7.47 (m, 5H); [ESI(+)], m/z 429 (M+H)+.

Provenance & Evidence