Methyl iodide → HCID 68814415, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 2 of example 3. Thus, 4-bromo-3-methyl-2-phenyl-1H-indole (1.574 g, 5.5 mmol) was reacted with k-t-butoxide (0.648 g, 5.775 mmol) and methyl iodide (0.820 g, 5.775 mmol) in DMF (15 ml) to give the product (1.188 g, 3.957 mmol, 72%) as a colorless oil. 1H DMSO-d6) δ 2.39 (s, 3H), 3.55 (s, 3H), 7.05 (t, J=7.8 Hz, 1H), 7.23 (dd, J=0.8, 7.6 Hz, 1H), 7.42-7.45 (m, 2H), 7.47-7.51 (m, 2H), 7.55 (t, J=6.9 Hz, 2H); [ESI(+)], m/z 300/302 (M+H)+.

Provenance & Evidence